| 【第1日：2010年9月29日(水)】 |
| 9:30- 9:40 |
Introduction |
| 9:40-10:30 |
Peter Wright (Scripps, USA)
Intrinsically disordered proteins: novel targets for drug discovery? |
| 10:30-11:00 |
Yoshifumi Nishimura (Yokohama City Univ., Japan)
Disordered proteins and NMR screening of drug candidates |
| 11:00-11:40 |
Hideo Takahashi (Yokohama City Univ., Japan)
Molecular Interaction Analyses by NMR for Drug Development |
| 11:40-12:30 |
Gerhard Wagner (Harvard, USA)
Inhibitors of protein-protein interactions as anti-tumor and immune-suppressive drugs |
| 12:30-13:30 |
Lunch |
| 13:30-14:00 |
Takanori Kigawa (Riken, Japan)
NMR-based Drug Discovery Platform in RIKEN |
| 14:00-14:30 |
Tai-huang Huang (Academia Sinica, Taiwan)
Probing the Molecular Interactions in α-ketoacid Dehydrogenase Complexes-A Supra-macromolecular Machine and Drug Target for Cancer and Diabetes. |
| 14:30-15:00 |
Takaaki Miura (Chugai, Japan)
Enzyme reaction mechanism of human UDPGlcNAc pyrophosphorylase as revealed by SPR technology and its significance to fragment screening |
| 15:00-15:20 |
Intermission |
| 15:20-15:50 |
Hitoshi Sakashita (Astellas Pharma Inc., Japan)
Fragment Evolution: Protein Crystallography for Fragment Based Projects in Astellas Pharma Inc. |
| 15:50-16:20 |
Bong-Jin Lee (SNU, Korea)
Structural insight into Toxin-Antitoxin System of Helicobacter Pylori |
| 16:20-17:10 |
Wolfgang Jahnke (Novartis, Switzerland)
MR in an integrated drug discovery approach |
| 17:30-19:30 |
Banquet |
| 【第2日：2010年9月30日(水)】 |
| 9:30-10:20 |
Mitsuhiko Ikura (Univ. Toronto, Canada)
NMR studies on molecular interactions in cell signaling: weak, intermediate, or tight binding |
| 10:20-10:50 |
Yutaka Ito (Tokyo Metropolitan Univ., Japan)
In-cell NMR studies of protein structure and dynamics inside living cells |
| 10:50-11:30 |
Masahiro Shirakawa (Kyoto Univ., Japan)
Investigation of intracellular space by in-cell NMR and opto-magneto detection using nanoparticles |
| 11:30-12:20 |
Christian Griesinger (MPI, Germany)
NMR based drug development and mechanism in Neurodegeneration |
| 12:20-13:20 |
Lunch |
| 13:20-14:10 |
Thomas L. James (UCSF, USA)
Targeting Three-Dimensional RNA Structure: Small Molecule Ligand Discovery Using Flexible Docking and NMR |
| 14:10-14:50 |
Bin Xia (Peking Univ., China)
A Common DNA Binding Mechanism Shared by Nucleoid-Associated Proteins H-NS from Gram-Negative Bacteria and Lsr2 from Gram-Positive Bacteria |
| 14:50-15:20 |
Sam-Yong Park (Yokohama City Univ., Japan)
The structural basis for an essential subunit interaction in influenza virus RNA polymerase |
| 15:20-15:40 |
Intermission |
| 15:40-16:30 |
Gregg Siegal (ZoBio,The Netherlands)
Into the great unknown: Fragment Based Drug Discovery on Membrane Proteins |
| 16:30-17:00 |
Ichio Shimada (Univ. Tokyo, Japan)
Functional analyses of membrane proteins by NMR |
| 17:00-17:50 |
Volker Dotsch (Univ. Frankfurt, Germany)
Combination of cell-free expression and NMR for the characterization of membrane proteins as drug targets |
| 17:50-18:00 |
Closing |